Mammalian cDNA
ABclonal Technology ACVRL1 Rabbit mAb
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
ABclonal Technology BRCA1 Rabbit pAb
This gene encodes a 190 kDa nuclear phosphoprotein that helps maintain genomic stability and functions as a tumor suppressor. It spans 22 exons over ~110 kb and forms part of the BRCA1-associated genome surveillance complex (BASC), interacting with DNA repair proteins and RNA polymerase II. Through its C-terminal domain, it also associates with histone deacetylase complexes, contributing to transcription regulation, DNA repair, and recombination. Mutations in BRCA1 account for ~40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects its localization and function, with many transcript variants described, some linked to disease. A related pseudogene also exists on chromosome 17.
Sino Biological Human, Insulin Receptor cDNA ORF Clone, untagged
Full length Clone DNA of Human insulin receptor transcript variant 1.